{"id":296931,"date":"2022-12-29T05:51:54","date_gmt":"2022-12-29T08:51:54","guid":{"rendered":"https:\/\/www.notibras.com\/site\/?p=296931"},"modified":"2022-12-29T05:52:51","modified_gmt":"2022-12-29T08:52:51","slug":"ratos-de-laboratorio-com-coca-revelam-segredos-do-vicio","status":"publish","type":"post","link":"https:\/\/www.notibras.com\/site\/ratos-de-laboratorio-com-coca-revelam-segredos-do-vicio\/","title":{"rendered":"Ratos de laborat\u00f3rio com coca revelam segredos do v\u00edcio"},"content":{"rendered":"<p>Uma equipe de pesquisadores chineses anunciou a descoberta do que pode muito bem ser uma vis\u00e3o potencial do mecanismo por tr\u00e1s do uso compulsivo de drogas.<\/p>\n<p>Os autores do novo estudo, publicado na revista <em>Science Advances<\/em> esta semana, ensinaram v\u00e1rios ratos de laborat\u00f3rio a auto-administrar coca\u00edna antes de introduzir uma puni\u00e7\u00e3o de choque nas patas, tornando assim o procedimento de ingest\u00e3o de drogas doloroso para os roedores.<\/p>\n<p>Os pesquisadores observaram que cerca de 66% dos ratos, aqueles considerados \u201csens\u00edveis ao choque\u201d, reduziram rapidamente a autoadministra\u00e7\u00e3o de coca\u00edna, enquanto os 34% restantes, os \u201cresistentes ao choque\u201d, continuaram a se entregar apesar do desconforto que acabaram infligindo a si mesmos no processo.<\/p>\n<p>A equipe notou que os ratos que exibiam uso compulsivo de drogas, que \u00e9 \u201ccaracterizado pelo uso persistente de subst\u00e2ncias apesar das consequ\u00eancias adversas\u201d, exibiam um \u201caumento da atividade neural do c\u00f3rtex insular anterior (aIC)\u201d em compara\u00e7\u00e3o com os ratos que n\u00e3o adotaram um comportamento compulsivo.<\/p>\n<p>\u201cA atividade de manipula\u00e7\u00e3o quimiog\u00eanica dos neur\u00f4nios aIC, especialmente os neur\u00f4nios glutamat\u00e9rgicos aIC, apontaram consumo compulsivo de coca\u00edna regulado bidirecionalmente. Al\u00e9m disso, o aIC recebeu informa\u00e7\u00f5es do c\u00f3rtex orbitofrontal (OFC) e o circuito OFC-aIC foi aprimorado em ratos com uso compulsivo de coca\u00edna\u201d, escreveram os pesquisadores.<\/p>\n<p>\u201cA supress\u00e3o do circuito OFC-aIC mudou os ratos da resist\u00eancia \u00e0 puni\u00e7\u00e3o para a sensibilidade, enquanto a potencializa\u00e7\u00e3o desse circuito aumentou o uso compulsivo de coca\u00edna\u201d. A equipe expressou esperan\u00e7a de que seu trabalho possa ajudar a obter mais informa\u00e7\u00f5es sobre a natureza do uso compulsivo de drogas e auxiliar no desenvolvimento de terapias para o tratamento da depend\u00eancia qu\u00edmica.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Uma equipe de pesquisadores chineses anunciou a descoberta do que pode muito bem ser uma vis\u00e3o potencial do mecanismo por tr\u00e1s do uso compulsivo de drogas. Os autores do novo estudo, publicado na revista Science Advances esta semana, ensinaram v\u00e1rios ratos de laborat\u00f3rio a auto-administrar coca\u00edna antes de introduzir uma puni\u00e7\u00e3o de choque nas patas, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":296932,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[155],"tags":[95],"class_list":["post-296931","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-leitura-vip","tag-capa"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ratos de laborat\u00f3rio com coca revelam segredos do v\u00edcio - Notibras<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.notibras.com\/site\/ratos-de-laboratorio-com-coca-revelam-segredos-do-vicio\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ratos de laborat\u00f3rio com coca revelam segredos do v\u00edcio - Notibras\" \/>\n<meta property=\"og:description\" content=\"Uma equipe de pesquisadores chineses anunciou a descoberta do que pode muito bem ser uma vis\u00e3o potencial do mecanismo por tr\u00e1s do uso compulsivo de drogas. Os autores do novo estudo, publicado na revista Science Advances esta semana, ensinaram v\u00e1rios ratos de laborat\u00f3rio a auto-administrar coca\u00edna antes de introduzir uma puni\u00e7\u00e3o de choque nas patas, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.notibras.com\/site\/ratos-de-laboratorio-com-coca-revelam-segredos-do-vicio\/\" \/>\n<meta property=\"og:site_name\" content=\"Notibras\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/notibras\/\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-29T08:51:54+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-12-29T08:52:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.notibras.com\/site\/wp-content\/uploads\/2022\/12\/rato.coa_.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Reda\u00e7\u00e3o\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Notibras\" \/>\n<meta name=\"twitter:site\" content=\"@Notibras\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Reda\u00e7\u00e3o\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.notibras.com\\\/site\\\/ratos-de-laboratorio-com-coca-revelam-segredos-do-vicio\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.notibras.com\\\/site\\\/ratos-de-laboratorio-com-coca-revelam-segredos-do-vicio\\\/\"},\"author\":{\"name\":\"Reda\u00e7\u00e3o\",\"@id\":\"https:\\\/\\\/www.notibras.com\\\/site\\\/#\\\/schema\\\/person\\\/36ab0979449956132d3e5b517ea76ac8\"},\"headline\":\"Ratos de laborat\u00f3rio com coca revelam segredos do v\u00edcio\",\"datePublished\":\"2022-12-29T08:51:54+00:00\",\"dateModified\":\"2022-12-29T08:52:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.notibras.com\\\/site\\\/ratos-de-laboratorio-com-coca-revelam-segredos-do-vicio\\\/\"},\"wordCount\":303,\"publisher\":{\"@id\":\"https:\\\/\\\/www.notibras.com\\\/site\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.notibras.com\\\/site\\\/ratos-de-laboratorio-com-coca-revelam-segredos-do-vicio\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.notibras.com\\\/site\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/rato.coa_.webp\",\"keywords\":[\"capa\"],\"articleSection\":[\"Leitura Vip\"],\"inLanguage\":\"pt-BR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.notibras.com\\\/site\\\/ratos-de-laboratorio-com-coca-revelam-segredos-do-vicio\\\/\",\"url\":\"https:\\\/\\\/www.notibras.com\\\/site\\\/ratos-de-laboratorio-com-coca-revelam-segredos-do-vicio\\\/\",\"name\":\"Ratos de laborat\u00f3rio com coca revelam segredos do v\u00edcio - 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