{"id":47293,"date":"2015-05-07T11:14:25","date_gmt":"2015-05-07T14:14:25","guid":{"rendered":"http:\/\/www.notibras.com\/site\/?p=47293"},"modified":"2015-05-07T11:16:30","modified_gmt":"2015-05-07T14:16:30","slug":"estudo-inedito-da-unb-revela-novos-genes-por-tras-do-gigantismo","status":"publish","type":"post","link":"https:\/\/www.notibras.com\/site\/estudo-inedito-da-unb-revela-novos-genes-por-tras-do-gigantismo\/","title":{"rendered":"Estudo in\u00e9dito da UnB revela novos genes por tr\u00e1s do gigantismo"},"content":{"rendered":"

Pesquisadores acabam de descobrir que a causa do gigantismo \u2013 problema que atinge 60 em 1 milh\u00e3o de pessoas no mundo \u2013 pode estar relacionada \u00e0 duplica\u00e7\u00e3o de parte do cromossomo X. Divulgada no ano passado, a s\u00edndrome \u00e9 chamada de X-Lag.<\/p>\n

Essa muta\u00e7\u00e3o gen\u00e9tica, segundo os estudiosos, pode estar por tr\u00e1s dos tumores na hip\u00f3fise causadores da doen\u00e7a, que \u00e9 marcada por crescimento excessivo \u2013 o paciente pode atingir mais de 2,20m de altura \u2013 e retardo mental.<\/p>\n

A hip\u00f3fise \u00e9 a gl\u00e2ndula no c\u00e9rebro que regula a secre\u00e7\u00e3o dos horm\u00f4nios, entre eles o do crescimento.<\/p>\n

\n

“O que se sabia at\u00e9 h\u00e1 pouco tempo \u00e9 que o aparecimento desse tipo de tumor estava relacionado a muta\u00e7\u00f5es nos cromossomos 11 e 17, de um total de 46 existentes no cari\u00f3tipo humano”, explica a professora Luciana Naves (foto), da Faculdade de Medicina da UnB.<\/p>\n<\/blockquote>\n

A pesquisadora diz que apenas 15% dos casos de gigantismo s\u00e3o causados por falhas nesses dois cromossomos.<\/p>\n

“A altera\u00e7\u00e3o no chamado bra\u00e7o longo do cromossomo X est\u00e1 entre as poss\u00edveis causas do problema que afeta o restante das pessoas que sofrem com o dist\u00farbio”, destaca Naves, ao falar sobre o X-Lag.<\/p>\n

Segundo ela, a idade em que o problema aparece e o local onde surgem os tumores s\u00e3o as principais diferen\u00e7as entre o gigantismo causado por falha no cromossomo X e nos cromossos 11 e 17.<\/p>\n

A professora explica que, no caso do X-Lag, os tumores aparecem na hip\u00f3fise e a doen\u00e7a se manifesta antes dos 8 anos. No outro caso, os tumores podem surgir em v\u00e1rias partes do corpo e o problema se manifesta entre os 14 e 20 anos de idade.<\/p>\n

\"Marcelo

Marcelo Jatob\u00e1\/UnB Ag\u00eancia<\/p><\/div>\n

\n

Genoma
\n<\/strong>Al\u00e9m da UnB, participaram da pesquisa a Universidade de Li\u00e8ge na B\u00e9lgica e o Minist\u00e9rio da Sa\u00fade americano (NIH, na sigla em ingl\u00eas), os dois maiores centros de estudo do genoma humano no mundo. A pesquisa contou com o apoio do laborat\u00f3rio brasileiro Sabin.<\/p>\n

“A identifica\u00e7\u00e3o do cromossomo espec\u00edfico \u00e9 feita ap\u00f3s todo o mapeamento gen\u00e9tico”, explica Naves.<\/p>\n

\u00danico centro de pesquisa no Brasil a participar do estudo, a UnB est\u00e1 entre as institui\u00e7\u00f5es de ponta em pesquisa gen\u00e9tica na \u00e1rea de endocrinologia. “No HUB<\/a>, 210 pacientes s\u00e3o acompanhados regularmente”, diz a pesquisadora.<\/p>\n

Premiada duas vezes, a pesquisa foi publicada nas revistas especializadas New England Journal of Medicine e Endocrine Related Cancer.<\/p>\n

Tamb\u00e9m fazem parte do grupo de pesquisa na UnB o professor Luiz Augusto Casulari e os doutorandos Lara Porto e Juliano Zakir.<\/p>\n<\/blockquote>\n

Erika Suzuki, UnB<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Pesquisadores acabam de descobrir que a causa do gigantismo \u2013 problema que atinge 60 em 1 milh\u00e3o de pessoas no mundo \u2013 pode estar relacionada \u00e0 duplica\u00e7\u00e3o de parte do cromossomo X. Divulgada no ano passado, a s\u00edndrome \u00e9 chamada de X-Lag. Essa muta\u00e7\u00e3o gen\u00e9tica, segundo os estudiosos, pode estar por tr\u00e1s dos tumores na […]<\/p>\n","protected":false},"author":1,"featured_media":47295,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"tmauthors":[],"class_list":["post-47293","post","type-post","status-publish","format-standard","has-post-thumbnail","category-brasilia"],"acf":[],"yoast_head":"\nEstudo in\u00e9dito da UnB revela novos genes por tr\u00e1s do gigantismo - Notibras<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.notibras.com\/site\/estudo-inedito-da-unb-revela-novos-genes-por-tras-do-gigantismo\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Estudo in\u00e9dito da UnB revela novos genes por tr\u00e1s do gigantismo - Notibras\" \/>\n<meta property=\"og:description\" content=\"Pesquisadores acabam de descobrir que a causa do gigantismo \u2013 problema que atinge 60 em 1 milh\u00e3o de pessoas no mundo \u2013 pode estar relacionada \u00e0 duplica\u00e7\u00e3o de parte do cromossomo X. Divulgada no ano passado, a s\u00edndrome \u00e9 chamada de X-Lag. 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